Anti-hyperglycemic and Anti-hyperlipidemic effect of combined plant extract of Cassia auriculata and Aegle marmelos in streptozotocin (STZ) induced diabetic albino rats

Cassia auriculata and Aegle marmelos are used extensively in the indigenous system of medicine as an anti-diabetic agent. The current investigation focuses on the serum insulin augmentation, anti-hyperglycemic and anti-hyperlipidemic property of a combined aqueous extracts of C.auriculata and A.marmelos on streptozotocin induced diabetic rats. The diabetes induced animals were fed with plant extracts at the increasing dosage of 250mg, 350mg and 450mg of body wt. The combined plant extracts administrated animals revealed a significant (P<0.001) increment of serum insulin levels, higher reduction in hyperglycemia and hyperlipidemia when compared to the diabetic control rats (P<0.001). The histological studies of the endocrine region of pancreas of diabetic animals revealed that shrinkage of β cells of islets of langerhans. The combined plant extracts treated animals revealed restoration of β-cells. The restoration of β cells was evident at higher dose level i.e. 450mg/by wt extracts fed groups.